Brucella canis induces canine CD4+ T cells multi-cytokine Th1/Th17 production via dendritic cell activation
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چکیده
منابع مشابه
The Effect of Beta Interferon on Dendritic Cells and Cytokine Synthesis by CD4+ T Cells
Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...
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Orientia tsutsugamushi, a gram-negative bacterium, causes severe acute febrile illness in humans. Despite this danger, the route of infection, infectivity, and protective mechanisms of the host's immune response to O. tsutsugamushi are unclear. Dendritic cells (DCs) are one of the most important cell types in bridging the innate and adaptive immune responses. In this study, we observed that O. ...
متن کاملCanine Brucellosis: Brucella canis
Canine brucellosis, caused by Brucella canis, is an important cause of reproductive failure, particularly in kennels. This organism causes abortions, stillbirths, epididymitis, orchitis and sperm abnormalities in dogs. Although dogs that have been spayed or neutered do not have reproductive signs, they occasionally develop other conditions such as ocular disease and discospondylitis. B. canis c...
متن کاملLactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function.
BACKGROUND Although it is widely recognized that the intake of so-called probiotic microorganisms is beneficial in chronic mucosal inflammation and topical allergic disease, the immunologic details explaining how such bacteria can exert these effects remain obscure. OBJECTIVE We determined whether Lactobacillus rhamnosus can modulate T cell responses in vitro and in vivo. DESIGN In vitro, h...
متن کاملthe effect of beta interferon on dendritic cells and cytokine synthesis by cd4+ t cells
background: dendritic cells (dc) are a key regulator of the immune response, and interferon- beta (ifn-β) is considered an immunomodulatory molecule for dc. objective: the purpose of this study was to evaluate the ability of ifn-β treated dc to induce cytokine secretion by cd4+ t cells. methods: dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...
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ژورنال
عنوان ژورنال: Comparative Immunology, Microbiology and Infectious Diseases
سال: 2019
ISSN: 0147-9571
DOI: 10.1016/j.cimid.2018.11.017